- Six new Litagion agent profiles and a new theme summarizing CoMeta content related to bisphenol A replacement chemicals
- New blog content: "Replacing BPA requires industry and regulators to think outside the box"
- Updated Litagion agent and company profiles impacted by newly published peer-reviewed science and newly gathered company information
- Bisphenol A replacements. Some seven billion pounds of bisphenol A (BPA) is used each year to manufacture polycarbonate plastic and epoxy resin incorporated in a wide range of products including plastic food storage containers, food and beverage cans, water pipes, thermal receipts, and dental resins. With scientists, lawmakers, and regulators concerned about the safety of BPA, alternatives to BPA are finding their way into the same "BPA-free" products. Although there is far less published science investigating BPA replacement chemicals, what little research there is suggests many could ultimately be found to pose similar risks to human health.
- Artificially sweetened beverages. Beverages containing the artificial sweeteners aspartame, D-allulose, saccharin, stevioside, and sucralose.
- Bisphenol B (BPB). A bisphenol A replacement chemical employed in a wide range of manufacturing processes including in the production of polyvinyl chloride and epoxy resins.
- Bisphenol F (BPF). A bisphenol A replacement chemical employed in a wide range of manufacturing processes including in the production of polyvinyl chloride and epoxy resins.
- Propionate. A short-chain fatty acid used as a preservative in baked goods, beverages, and dairy products.
- Tetramethyl bisphenol F (TMBPF). A bisphenol A replacement chemical used to manufacture epoxy resins that provide a protective lining in food and beverages cans.
- Tritan. A bisphenol A replacement chemical manufactured by the Eastman Chemical Company used in a wide range of plastic products including baby bottles, food containers, household appliances, and medical devices.
Updated Litagion agents based on newly published science
All Litagion agent profiles have been updated to reflect the most recently published peer-reviewed science. Notable scientific studies added to CoMeta since the last release include:
- Cannabis (inhaled). A study of young adults found current and frequent cannabis use is significantly associated with lower accuracy in verbal learning and memory.
In addition, we highlight the following changes to the components of Litagion agent risk resulting from newly published peer-reviewed science:
|Litagion agent||Risk category change||Overall risk change|
|Dichloroacetic acid (DCA)||Projected science risk changes from Low (green) to Medium-low (light green)||No change|
Perfluoroundecanoic acid (PFUnA)
|Projected science risk changes from Medium-low (light green) to Medium (yellow)||No change|
Pharmaceutical content deprecated
As of this release, CoMeta no longer contains pharmaceutical content. Going forward, users should log-in to ChemMeta for this content instead (contact your account manager for access). ChemMeta monitors the peer-reviewed science and FDA adverse event data for more than 1,500 active pharmaceutical ingredients. Pharmaceutical content will return to CoMeta upon completion of a probabilistic pharmaceutical mass litigation model.