This release of CoMeta includes seven new Litagion agent profiles, a new theme summarizing CoMeta content related to phthalates, and a host of updated Litagion agent and company profiles impacted by newly published peer-reviewed science and newly gathered company information.
New Content
Themes
- Phthalates. Phthalates are a class of chemicals used to soften polyvinyl chloride (PVC) and other plastics. Phthalates are also used as solvents in a range of consumer products and industrial processes. Medical devices, food packaging, adhesives, detergents, shampoos, and vinyl flooring, wall coverings, clothing, and many other vinyl and plastic products rely on phthalates to enhance flexibility and durability. Because of their potential to disrupt the normal functioning of the endocrine system, the United States and other countries have imposed restrictions on the use of some phthalates like DEHP, BBP, and DBP, especially in children’s products. While phthalates remain the main plasticizing agent used worldwide, some phthalate replacement chemicals like DEHT, DINCH, and DEGBD are becoming more common.
Litagion agents
- Crumb Rubber. A product made from recycled tires used as infill for artificial turf.
- Di(2-ethylhexyl) terephthalate (DOTP). A non-phthalate replacement for di(2-ethylhexyl) phthalate (DEHP).
- Diallyl phthalate. A phthalate used as a plasticizer.
- Dimethyl phthalate. A phthalate used as a plasticizer.
- 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH). A non-phthalate replacement for DEHP.
- Diundecyl phthalate. A phthalate used as a plasticizer.
- Microplastic. Pieces of plastic smaller than five millimeters.
Updated Litagion agents based on newly published science
In this release, all Litagion agent profiles have been updated to reflect the most recently published peer-reviewed science. Notable scientific studies added to CoMeta since the last release include:
- Bisphenol A (BPA): A meta-analysis with 41,320 subjects reported a statistically significant association between BPA exposure and type 2 diabetes.
In addition, we highlight the following changes to the components of Litagion agent risk resulting from recently published peer-reviewed science:
| Litagion agent | Risk category change | Overall risk change |
|---|---|---|
| Perfluorodecanoic acid (PFDA) | Projected science risk increased from Medium (yellow) to Medium-low (orange) | None |
| Triphenyl Phosphate | Projected science risk increased from Medium-high (orange) to High (red) | None |