This release of CoMeta includes four new Litagion agent profiles, a new theme summarizing CoMeta content related to per- and polyfluoroalkyl substances, and a host of updated Litagion agent and company profiles impacted by newly published peer-reviewed science and newly gathered company information.
- Per- and polyfluoroalkyl substances (PFAS). A class of 3,000 organic chemicals containing at least one fully flourinated carbon atom. PFAS are employed in myriad industrial processes such as metal plating, photolithography, and semiconductor manufacturing and in consumer products such as stain- and water-repellant textiles, non-stick cookware, waxes, and cleaning products. PFAS are also a critical component of firefighting foams used at airports, military bases, and other locations. Ongoing litigation over two PFAS – PFOA and PFOS – alleges widespread contamination of drinking water and adverse health effects. PFOA and PFOS have been phased out in the U.S. along with other “long-chain” PFAS, but a range of short-chain PFAS, such as GenX, are still in use. Scientists, regulators, and the plaintiffs’ bar are paying close attention to how the biomedical science is developing for these substitute chemicals.
- GenX. A perfluorinated compound, first manufactured by DuPont in 2009 as a replacement for perfluorooctanoic acid (PFOA).
- Perfluorododecanoic acid (PFDoA). A perfluorinated compound with twelve carbons and many of the same applications as PFOA.
- Perfluoroheptanoic acid (PFHpA). A perfluorinated compound with seven carbons and many of the same applications as PFOA.
- Psciose. A non-caloric monosaccharide sweetener with the same taste and texture as table sugar.
Updated Litagion agents based on newly published science
In this release, all Litagion agent profiles have been updated to reflect the most recently published peer-reviewed science. Notable scientific studies added to CoMeta since the last release include:
- Nickel: A study in China found maternal nickel levels in urine during pregnancy were significantly associated with preterm delivery.
In addition, we highlight the following changes to the components of Litagion agent risk resulting from recently published peer-reviewed science:
|Litagion agent||Risk category change||Overall risk change|
|Mancozeb||Projected science risk score changes from Medium-low (light green) to Medium (yellow)||None|
|Perfluorodecanoic Acid||Projected science risk score changes from Medium-low (light green) to Medium (yellow)||Increase from Medium-low (light green) to Medium (yellow)|