This release of CoMeta includes two new chemical Litagion® agent profiles, five updated company profiles, and a host of updated Litagion agent profiles impacted by newly published peer-reviewed science.
New Litagion agent profiles
- Carbon tetrachloride
- N-methyl-2-pyrrolidone
Updated company profiles
- Linde AG
- LyondellBasell Industries N.V.
- Mars, Incorporated
- Olin Corporation
- Silgan Holdings Inc.
Updated Litagion agents based on newly published science
In this release, all Litagion agent profiles have been updated to reflect recently published peer-reviewed literature. We provide more detail below for two of the Litagion agents that experienced changes in their general causation risk score (GC risk score) since the last CoMeta release.
- Tetrachloroethylene (perc): A study on occupational exposure to tetrachloroethylene found workers using this chlorinated solvent have a significantly elevated risk of kidney cancer.
- Dichloromethane: Children with acute myeloid leukemia, a form of blood cancer, may have developed the disease from ambient exposure to dichloromethane.
In addition, we want to highlight the most significant changes in the overall risk for the following Litagion agents as the result of recently published peer-reviewed literature:
| Litagion agent | Risk category change | Overall risk change |
|---|---|---|
| Bis(2-ethylhexyl) tetrabromophthalate (TBPH) | Projected science risk changed from Medium risk (yellow) to Medium-high risk (orange) | None |
| Copper nanoparticles | Projected science risk changed from Medium-high risk (orange) to High risk (red) | None |