This release includes one new chemical Litagion® agent profile, two updated company profiles, and updated Litagion agent profiles impacted by newly published science. This release also includes a redesigned version of the general causation risk plot displayed within the Science Risk section of Litagion agent profiles.
New Litagion agent profiles
- Amiodarone hydrochloride (Cordarone). Amiodarone hydrochloride is a treatment for irregular heartbeat. It may be administered before and after cardiac surgery. Amiodarone hydrochloride may also be prescribed as a long-term treatment for patients with heart disease.
Updated company profiles
- Evonik Industries AG
- The Mosaic Company
Updated Litagion agents based on newly published science
In this release, all Litagion agent profiles have been updated to reflect recently published peer-reviewed literature. We provide more detail below for several Litagion agents that experienced changes in their general causation risk score (GC risk score) since the last CoMeta release.
- Dietary Salt: A meta-analysis using data from 11 studies confirms a link between dietary salt and and the development of osteoporosis.
- Oxybenzone: A study in Chile revealed a significant association in urine levels of oxybenzone and early menarche in females.
In addition, we want to highlight the most significant changes in the overall risk for the following Litagion agents as the result of recently published peer-reviewed literature:
| Litagion agent | Risk category change | Overall risk change |
|---|---|---|
| Carbaryl | Projected science risk changed from Low (green) to Medium-Low (light green). | None |
| Tetrabromobisphenol A | Projected science risk changed from Medium (yellow) to Medium-High (orange). | None |
Revised general causation risk plot
The general causation (GC) risk plot available to CoMeta users in the Science Risk section of Litagion agent profiles has been redesigned to display both historical and projected GC risk scores (1) and to allow users to select which harms to display (2). Users can select which projection statistic (e.g., expected value (EV), median-50th percentile) to display for all selected harms (3) or choose to display the full distribution of projected GC risk scores for any one harm (4).
Users can also now display GC risk scores in table format (5). The "GC" column of the table displays the GC risk score for the selected historical year (6), whereas the columns shaded in blue display statistics corresponding to the projected GC score in the selected projected year (7).
