This release of CoMeta adds four new chemical Litagion® agents, one new company profile, two updated company profiles, and updated Litagion agent profiles impacted by newly published science.
New Litagion agent profiles
- 2,3,7,8-Tetrachlorodibenzodioxin (TCDD). TCDD is released into the environment from the production and use of chlorinated chemicals. Smelting and hazardous waste treatment also release TCDD into the environment. The highest current general causation risk score for TCDD is 0.72 for endocrine injury.
- Dichlorodiphenyltrichloroethane (DDT). DDT is a pesticide used against mosquitoes for malaria prevention. It is highly bioaccumulative and persistent in the environment. The highest current general causation risk score for DDT is 0.65 for reproductive injury.
- Dieldrin. Dieldrin is a pesticide formerly used in termite treatment. It is highly bioaccumulative and persistent in the environment. The highest current general causation risk score for dieldrin is 0.45 for nervous system injury.
- Endrin. Endrin is a pesticide formerly used in agriculture. It is highly bioaccumulative and persistent in the environment. The highest current general causation risk score for endrin is 0.28 for nervous system injury.
New company profiles
- Perstorp Group
Updated company profiles
- Ecolab Inc.
- Helena Chemical Company
Updated Litagion agents based on newly published science
In this release, all Litagion agent profiles have been updated to reflect recently published peer-reviewed literature. We provide more detail below for several Litagion agents that experienced changes in their general causation risk score (GC risk score) since the last CoMeta release.
- Perfluorobutanesulfonic acid (PFBS): Two studies on the reproductive effects of PFBS found associations in male and female fertility. PFBS was linked to sperm immobility in males. Another study revealed PFBS was significantly linked to endometriosis in females.
- Styrene: A Danish study on reinforced plastic workers found a significant association between styrene exposure and acute myeloid leukemia.
In addition, we want to highlight the most significant changes in the overall risk for the following Litagion agents as the result of recently published peer-reviewed literature:
| Litagion agent | Risk category change | Overall risk change |
|---|---|---|
| 2,3-pentadione | Projected science risk changed from Medium (yellow) to Medium-High (orange) | None |
| Triphenyl Phosphate | Projected science risk changed from Medium-High (orange) to High (red) | None |